I love love this product and has made my skin feel so much stronger and hydrated without breaking me out! 100% recommend!
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This upgraded formula combines our signature peptide complex with plant stem cell extracts, hyaluronic acid, coenzyme Q10, Edelweiss stem cells, Kakadu plum, and plant-derived exosomes rich in botanical antioxidants, polyphenols, naturally occurring enzymes, and protective plant lipids.
Rather than chasing quick fixes or aggressive correction, this serum helps support healthier-looking skin by improving hydration, reinforcing the skin barrier, and promoting overall skin resilience over time.
Suitable for virtually every skin type, including sensitive, dehydrated, and acne-prone skin.
At BIBA LOS ANGELES, we're always looking for meaningful ways to improve our formulas. When plant-derived exosomes became available, they were the perfect complement to our Plant Stem Cell Serum, adding another layer of botanical support without changing the lightweight feel clients love.
This formula was carefully refined over many years while treating thousands of clients. Every change was guided by one simple question: How did the skin respond?
Many serums are formulated to aggressively correct skin concerns. While active ingredients certainly have their place, skin doesn't always thrive when it's constantly being pushed. That philosophy shaped this serum from the very beginning. Over the years, one thing became clear: skin tells you very quickly what it likes, and what it doesn't. This serum evolved by listening to those responses. Every refinement was made because it improved how the skin responded to the formula.
Hydration remains at the heart of this formula.
Well-hydrated skin is better able to maintain a healthy barrier, tolerate active ingredients, stays bright and recovers well from daily environmental stress.
For best results, apply the Plant Stem Cell Serum after the Hydrating Toner. The toner helps replenish water immediately after cleansing, while the serum helps maintain hydration and supports the skin barrier throughout the day or night.
The Plant Stem Cell Serum layers effortlessly beneath moisturizers, sunscreen, vitamin C, retinoids, niacinamide, and exfoliating acids, making it an ideal daily support serum for nearly every routine.
If your skin frequently feels dehydrated, reactive, tight, or inconsistent after using active ingredients, this serum helps restore hydration while supporting overall skin balance.
We typically don't recommend layering serums. Instead, think of them as complementing each other, Meta C Serum in the morning for antioxidant protection, and Plant Stem Cell Serum at night to replenish hydration and support the skin.
Created by celebrity esthetician Biba de Sousa after decades of treating acne-prone, reactive, and compromised skin, this serum reflects a philosophy developed through thousands of professional treatments.
Over the years, one pattern became clear: many skin concerns weren't caused by a lack of active ingredients, they were caused by skin that had lost its ability to function optimally.
This serum was designed to become the stabilizing step in virtually any routine, a daily layer that supports hydration, reinforces the skin barrier, and helps skin remain resilient even when using corrective products.
It's often the product clients reach for when their skin simply needs to feel healthy again.
Want to understand why peptides have been a cornerstone of my treatment room for years? Read How I Helped Bring Peptides Into the Skincare Conversation.
Supports Skin Resilience & Stability
Peptides and plant-derived exosomes help support the skin barrier, promoting healthier-looking skin that feels more balanced and resilient.
Improves Texture Without Aggressive Exfoliation
Helps refine the look and feel of the skin through hydration and barrier support rather than resurfacing or irritation.
Supports Firmness & Elasticity
Our signature peptide complex helps support the skin's natural structure for a smoother, firmer appearance over time.
Provides Long-Lasting Hydration
Hyaluronic acid, humectants, and botanical ingredients help maintain moisture, keeping skin comfortable, hydrated, and balanced.
Layers Beautifully with Active Ingredients
Designed to complement vitamin C, retinoids, niacinamide, and exfoliating acids while helping support skin comfort and tolerance.
Suitable for Sensitive & Acne-Prone Skin
Lightweight, fragrance-free, and non-greasy, this serum hydrates without feeling heavy or contributing to congestion.
Unlike many serums that focus primarily on correction, this formula was developed to support how the skin functions over time. Enhanced with plant-derived exosome technology, peptides, plant stem cells, and hydrators, it helps maintain hydration, support the skin barrier, and promote healthier-looking skin without overwhelming sensitive skin.
Will this serum hydrate my skin?
Yes. Hyaluronic acid, panthenol, and other humectants help attract and retain moisture, while plant-derived exosomes, peptides, and botanical ingredients support a healthy skin barrier. The result is skin that feels more comfortable, hydrated, and balanced.
Is this serum safe for sensitive or acne-prone skin?
Yes. The lightweight, fragrance-free formula was developed for sensitive, reactive, dehydrated, and acne-prone skin. It hydrates without feeling heavy or greasy and layers well with most skincare routines.
Can I use this serum with retinol, vitamin C, or exfoliating acids?
Absolutely. This serum pairs beautifully with retinoids, vitamin C, niacinamide, and exfoliating acids. It helps support hydration and skin comfort while complementing active skincare routines.
How long will one bottle last?
With twice-daily use, one bottle typically lasts 6–8 weeks, depending on how many pumps you apply and the areas being treated.
When should I apply it?
Apply after cleansing and toning and before moisturizer. It can be used morning and evening and layers well under sunscreen during the day.
What are plant-derived exosomes?
Plant-derived exosomes are naturally occurring microscopic lipid vesicles that carry beneficial botanical compounds, including antioxidants, polyphenols, plant lipids, and naturally occurring enzymes. In our formula, they complement our signature blend of peptides and plant stem cell technology to provide additional botanical support.
Aqua, Natural Sodium Hyaluronate (Hyaluronic Acid), Palmitoyl Tripeptide-38 (Plant Peptide), Organic Leontopodium Alpinum (Edelweiss) Extract, Ubiquinone (CoQ10), Echinacea Plant Stem Cell, Palmitoyl Tripeptide-5 (Plant Peptide), Hydroxyethylcellulose, Panthenol (Vitamin B5), Natural Tocopherol (Vitamin E), Terminalia Ferdinandiana (Kakadu plum) fruit extract, Asparagus Officinalis Stem Extract, Malus Domestica fruit extract, Citrus Reticula (Tangerine) fruit extract, Carica Papaya (Papaya) fruit extract (and maltodextrin), Caprylyl Glycol, Citric Acid
INGREDIENT INTEGRITY
Professionally formulated skin care. Cruelty Free. Made in the USA with globally sourced components and ingredients. No Parabens, Ethanol, SLS, Corn, Gluten, Talc, Triclosan, Fragrance, Sulfate-free, and Silicone-free.
This product is not intended for use by anyone under age 13.
Choose options
Apply after cleansing and toning, before moisturizer.
Use morning and/or evening
Layers well with actives
Follow with moisturizer to support barrier function.
Overall rating: 4.9 / 5 from 137 reviews.
I love love this product and has made my skin feel so much stronger and hydrated without breaking me out! 100% recommend!
Nadia B. 5/5 Verified
Excellent collagen-builder. This is one of those all-star serums where my skin looks the best when I use it regularly.
Tiffany S. 5/5 Verified
Biba de Sousa's Plant Peptide Serum works so well. I am super into skincare and I get compliments on my skin from makeup artists (when I am on set, acting and modeling). I first learned about Biba's Plant Peptide Serum from Hailey Bieber, where she recommended it in an article. It has been excellent ever since. 5 stars!
Tiffany S. 5/5 Verified
Love it! Perfecto for my dry skin
Victoria C. 5/5 Verified
makes my skin so soft, silky and smooth. i put around 4 drops one on my forehead and neck and two on my cheeks and it soaks right in so be fast with it depending on your skin type!
Nico C. 5/5 Verified
I really like this for my skin! I have acne prone and am dealing with scars and it makes my skin less red and softer! I’ve only had it for a couple days so I can’t justify it for the price just yet but so far so good’
Rithya B. 5/5 Verified
This product with the meta C is the multi tasking duo!
Abigail N. 4/5 Verified
I love this serum. Absorbs so well and leaves my skin fresh, firm and healthy-looking. Fabulous under make-up, and other products such as moisturizer or sunscreen layer on perfectly. A permanent addition to my routine!
Diane W. 5/5 Verified
Love it
Christopher C. 5/5 Verified
Love it .. my skin is looking fabulous!!
Alexis H. 5/5 Verified
Loving it
Raquel S. 5/5 Verified
Excellent product and service!
Sana S. 5/5 Verified
I started using this serum about a year ago and have never looked back. I use it twice daily. It is the most hydrating non-greasy serum I’ve discovered. I have my normal facial regimen then enjoy the moment when I apply this serum that just sinks into my skin, it also helps my SPF glide on smoother. At 66 yrs young haha my skin feels plump and I feel fresh and rejuvenate. I now live near the beach and had no idea how much the salt air would affect my skin but this serum took everything to a new level. I literally look forward to using it.. truly!
Elizabeth G. 5/5 Verified
Love it! Skin has never looked better.
Amanda A. 5/5 Verified
The serum is great for layering with my moisturizer. It keeps my skin hydrated. I love that it is not scented and is suitable for my sensitive skin.
Andrea S. 5/5 Verified
Great product, my fav is the Plant Stem Cell Serum! Makes my 74-year-old skin look super healthy and not so delicate
Barbara B. 5/5 Verified
I love The Plant Stem Cell Serum it helps me fave stay nice and soft.
Krystal S. 5/5 Verified
Love it!
Amanda A. 5/5 Verified
Noticeable difference in my skin elasticity. Looks more plump and hydrated. Overall skin texture has improved significantly. Absolutely obsessed with how it feels on my skin. LOVE this brand so much
Danielle O. 5/5 Verified
Love it!
Jill M. 5/5 Verified
So far love it, very light, absorbs right away
Mary M. 5/5 Verified
Love this serum ! Skin looks smooth & hydrated !!! Will buy again for sure
Sharon B. 4/5 Verified
It’s a nice add in to your face care.. its hydrating and absorbs well..
Mandi D. 5/5 Verified
the best!!! always repurchase my absolute fave
Maria K. 5/5 Verified
It’s okay. I’ve bought it twice and didn’t finish the first bottle. You get what you pay for.
Logan W. 4/5 Verified
Amazing!
Kassandra K. 5/5 Verified
Great serum, very clean and penetrating
Abigail N. 5/5 Verified
Amazing serum! Absorbs quickly and makes my skin look so smooth!
Stacey B. 5/5 Verified
I'll be 73 and my skin has never looked better. After using Biba's Plant Stem Cell Peptide Serum for a week or so, I noticed that my skin looked less delicate--just healthier and stronger. Thanks Biba for this great product!
Barbara B. 5/5 Verified
Love this serum. It helps keep my skin hydrated and plump. Great base for my skincare!
J K. 5/5 Verified
This is my second bottle! It is so hydrating and I can see a difference in my skin, it looks more plump after I use it.
Anita J. 5/5 Verified
Love the serum! I notice a BIG difference!
Amy G. 5/5 Verified
I love this serum! My skin looks hydrated when I wake up. It is a must with the onerta cream 🫶
Anne-sophie F. 5/5 Verified
My clients are loving this product! And, I'm noticing a significant improvement in mature skin of 70-80 -year-olds, in particular, that can appear to be delicate. I see a more firm and healthier appearance after only a couple of weeks. Thanks, Biba!
Barbara B. 5/5 Verified
love the texture, it is so hydrating and dries fast.
Ghaida A. 5/5 Verified
Really the 5 stars my skin looks younger with a luminous appearance, and parts of my wrinkles no longer look strong have decreased what the product says is what it is.
Erik L. 5/5 Verified
Love the product!!
Yara 5/5 Verified
My skin has never been after after integrating this serum, alongside other Biba products into my daily skincare routine.
Autumn B. 5/5
I have been using it for a month, and my skin feels so much plumper after incorporating it into my routine. I haven't changed anything else in my routine, I only added this serum, so all the credit goes to it. The consistency is thick and it feels so hydrating when is on the skin, not tacky at all. Highly recommend!
Anita J. 5/5
This stuff is great! It is so hydrating. Not greasy at all!
Erin 5/5 Verified
